ELENA IVANOVNA ZAITZEVA (21.05.1921 - 03.10.2005), DOCTOR OF MEDICINE, PROFESSOR, HONORARY PROFESSOR OF SMOLENSK STATE MEDICAL ACADEMY, HONOURED SCIENCE WORKER OF RUSSIAN FEDERATION, HONORARY FREEMAN OF SMOLENSK
Khibin L.S., Podoprigorova V.G.
Abstract: Elena Ivanovna Zaitzeva (21.05.1921 - 03.10.2005), MD, Professor, honourable Professor of Smolensk state medical academy, Honoured Science Worker of Russian Federation, honorary freeman of Smolensk. She was born in Birsk, Bashkiriya, graduated from Stalinabad medical institute in 1944. She defended Candidate’s dissertation in 1950 and doctoral dissertation in 1958. She was a Chief of the propedeutics of internal diseases department in 1960-1992, Professor of this department in 1992-2004. Author of more than 300 scientific works, 3 inventions, educational-methodological textbooks, 14 innovations, organizer of 32 theoretical and practical conferencies with international participation and proceedings publication. Town council member for 7 convocations. She has government awards.
Key words: Зайцева Е. И, профессор, почетный гражданин, Смоленск, Zaitzeva E. I, Professor, honorary freeman, Smolensk
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CORRELATION BETWEEN HELICOBACTER PYLORI CONTAMINATION OF GASTRIC MUCOUS AND YEAR SEASONS
Afanasenkova T. E., Ilyushchenkov P. A., Livinskaya S. I.
UDC: 616. 33 - 002. 446
Abstract: In given work is studied, what influence renders the amount of the microorganism helicobacter pylori being kept in mucous shell of the belly on frequency of the intensifications of the chronic gastritis depending on time of the year beside patient, which were found on dispensary treatment. As a result of studies is installed that for chronic gastritis characteristic of intensification in autumn and spring periods. Not only presence of the microorganism in mucous shell of the belly, but also his(its) amount influence on degree of gravity of the chronic gastritis. For high degree of the infections Helicobacter pylori nature of the disease is expressed more distinctly.
Key words: гастрит, инфекция Helicobacter pylori, сезонность, gastritis, infection Helicobacter pylori, timeses of the year
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COMPARATIVE ASSESSMENT OF COMPLIANCE IN PATIENTS WITH GASTRITIS, CHRONIC HEPATITIS AND LIVER CIRRHOSIS IN CONDITION OF TREATMENT WITH DOCTOR OF GENERAL PRACTICE AND DISTRICT THERAPEUTIST
Afanasenkova T. E., Yankovaya T. N.
UDC: 616. 3 + 615. 015
Abstract: In the given work the analysis of the adherence to treatment and his factors in work of the family doctor and the therapeutic at conducting patients with gastroenterology a pathology. It is received, that the general parameter of adherence to treatment at patients taking place under supervision of the doctor of the general practice authentically is higher, than at patients treated at the therapeutic. Increase adherence to treatment at patients of the family doctor occurs due to medical-social adaptedness, medical -social knowledge, medical -social skill to communicate, trust to therapeutic strategy of the attending physician and productivity spent or before the carried out therapy. Higher parameter of adherence to treatment at patients of the family doctor in comparison with the local doctor the therapist, testifies to good prospects of the given speciality in our country.
Key words: комплаенс, врач общей практики, участковый терапевт, аdherence to treatment, the doctor of the general practice, therapeutic
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Volk S. V.
THE FEATURES OF THE LARGE INTESTINE MICROBIOCOENOSIS IN PATIENTS WITH PEPTIC ULCER DISEASE
Volk S. V.
UDC: 616.345:616.33-002.44
Abstract: Large intestine microbiocoenosis status considerably affects all aspects of human organism vital functions. Large intestine dysbiosis doesn’t depend on ulcerative defect localization, it is a component of clinical course of peptic ulcer disease acute phase and characterized mainly by large intestine microflora disturbancies of II and III degree.
Key words: язвенная болезнь, толстая кишка, кишечный микробиоценоз, дисбиоз толстой кишки, peptic ulcer disease, large intestine, intestinal microbiocoenosis, large intestine dysbiosis
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ULCERATIVE COLITIS AND KROHN’S DISEASE - XXI CENTURY PROBLEM
Grigoryeva G. A.
UDC: 616.344-002-031.84
Key words: воспалительные заболевания кишечника, болезнь Крона, язвенный колит, внекишечные проявления, кишечные осложнения, гипербарическая оксигенация, ингибиторы ФНО
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INTRASURGICAL AND EARLY POSTSURGICAL COMPLICATIONS ANALYSIS IN CASE OF CHOLECYSTECTOMY FROM MINI-ACCESS
Danilenkov N. V., Moskalyov A. P., Rodin A. V.
UDC: 616.366-089.87-031:616.381-072-1:[615.472.3:3:533-9]
Abstract: The results of 3078 mini-cholecystectomies show a significant improvement in indicators such as early postoperative complications and postoperative mortality.
Key words: холецистэктомия, минилапаротомный доступ, плазменный скальпель, осложнения, mini-cholecystectomy, plasmatic scalpel, complications
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H. PYLORI ANTIBIOTIC RESISTANCE: RESULTS OF MICROBIOLOGICAL LOCAL STUDY
Dekhnich N. N., Kostyakova T. A., Punin A. A., Alimov A. V., Ivanchik N. V., Kozlov R. S.
UDC: 616.33-002.44+615.33
Abstract: 210 adult patients with H. pylori-associated diseases with quick positive urease test were investigated. Н. pylori was secured in 64% patients. Н. pylori sensitivity to different antibiotics by the dilution in agar was determined. It was found resistance of 24 Н. pylori isolates to one antibiotic, 4 strains - to two and more drugs. Resistance rate to macrolids was 7,6%, to metronidazol - 3,8%. The resistant strains to amoxycilline and tetracycline were not revealed. Resistance rate to ciprofloxacin was 12,8%, to levofloxacin - 8,3%.
Key words: Helicobacter pylori, антибиотикорезистентность, макролиды, метронидазол, амоксициллин, Helicobacter pylori, antibiotics resistance, macrolides, metronidazol, amoxycilline
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PROTON PUMP INHIBITORS IN THE THERAPY OF ACID-ASSOCIATED GASTROINTESTINAL DISORDERS
Dekhnich N. N.
UDC: 616.33-002.44+615.33
Abstract: Proton pump inhibitors are basic drugs in acid-associated diseases therapy. Due to their efficiency and safety they supplanted M-cholinoblockers, gastrin receptors, antacids from acid-associated diseases therapy, including peptic ulcer disease, and excelled H -histamine blockers and antacids because of more efficiency.
Key words: ингибиторы протонной помпы, кислотозависимые заболевания, proton pump inhibitors, acid-associated diseases
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ELECTROMAGNETIC EMISSION OF MILLIMETRIC RANGE INFLUENCE ON MORPHOFUNCTIONAL STATE OF GASTRODUODENAL MUCOUS MEMBRANE IN PATIENTS WITH PEPTIC ULCER DISEASE
Ivanishkina E. V., Molchanov V. V., Podoprigorova V. G.
UDC: 616.33-002.44
Abstract: 52 patients with peptic ulcer disease for electromagnetic emission of millimetric range influence on morphofunctional state of gastroduodenal mucous membrane study were investigated. Electromagnetic emission of millimetric range application in complex treatment of patients with peptic ulcer disease leads to more expressive decrease pool of cells infiltrating gastroduodenal mucous membrane than standard eradicational therapy.
Key words: электромагнитное излучение, гастродуоденальная зона, язвенная болезнь, эрадикационная терапия, electromagnetic emission, gastroduodenal zone, peptic ulcer disease, eradicational therapy
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PROBLEM CATEGORIES OF THE PERFORATED GASTRODUODENAL ULCERS SURGERY
Kasumyan S. A., Snytko N. P., Timoshevsky A. A.
UDC: 616.33-002.44-002.45
Abstract: The article deals with experience in treating of patients with perforated gastroduodenal ulcers in Emergency Hospital of Smolensk during the period from 2005 to 2009. Differential approach is reasonable when selecting the method of surgical treatment of patients with perforated gastroduodenal ulcers. Mostly operation laparotomic suturing perforated ulcer. The studies of regional immune status in patients with complicated peptic ulcer disease, is being developed prognostic criteria for raising the question on the implementation of patients with peptic ulcer pre-emptive operations to the development of complications.
Key words: перфоративная, гастродуоденальная, язва, perforated, gastroduodenal, ulcer
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THE SYMPTOMS OF SOMATIC PATHOLOGY IN PREGNANT WOMEN
Konyshko N. A.
UDC: 618.3-007.17
Abstract: Several symptoms have been hypothesized to influence the risk of preeclampsia. Our aim in this study was to estimate the association between gastrointestinal patterns during pregnancy and the risk of gastritis, ulcer disease, preeclampsia, obesity and arterial hypertension in pregnant women. Women participating in study answered questionnaires. Exploratory factor analysis was used to assess the associations among variables. Principal component factor analysis identified 12 primary gastrointestinal patterns that were labeled: epigastric pain and dyspepsia. Relative risks of gastritis, preeclampsia, arterial hypertension were estimated as odds ratios (OR) and confounder control was performed with multiple logistic regression. Women with high scores on a pattern characterized by pain nausea, vomiting, disrexia, asthenic syndrome, constipation. These findings suggest that a dietary pattern characterized by high intake of vegetables, plant foods, increases the risk of dyspeptic disorders, whereas a medicines pattern characterized by high consumption of processed increases the risk.
Key words: беременность, гастроинтестинальная патология, гестоз, артериальная гипертензия, gastrointestinal patterns, pregnancy, preeclampsia, arterial hypertension
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DIFFICULTIES IN THE DIAGNOSIS AND TREATMENT OF THE GALLBLADDER CANCER
Lelyanov A. D., Kozlov D. V., Chelombitko M. A., Sergeev A. V., Timoshevsky A. A., Kazenkova S. V.
UDC: 616.366
Abstract: Retrospective analysis of 38 patients with diseases of gall bladder cancer was conducted. The reasons for late diagnosis were studied. Recommendations for early detection of disease and improve treatment outcomes were presented.
Key words: рак, желчный пузырь, классификация, диагностика, операции, рекомендации, cancer, gallbladder, classification, diagnosis, operations, recommendations
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THE DIAGNOSTIC ASPECTS OF DYSFUNCTIONAL DISTURBANCES OF THE BILIOUS BUBBLE IN OUT-PATIENT CONDITIONS
Moiseenkova L. S., Mikhalik D. S.
UDC: 616.366-072.7
Abstract: 38 patients with the dysfunctional disturbances of a bilious bubble in the age from 21 till 58 years old were examined. The high intensity of free-radical oxidation processes of blood lipids is show up during an aggravation of biliary dyskinesia on a background of the normal general anti-oxidation activity of blood whey is revealed. At a choice of pathogenetic therapy and after the lead rate of therapy, disterbances in system of the peroxide oxidation of lipids and of the anti-oxidation protection as the control over the efficiency of the treatment and the completeness of the remission of the disease should be considered.
Key words: дисфункциональные нарушения желчного пузыря, свободнорадикальное окисление липидов, хемилюминесценция, dysfunctional infringements of a bilious bubble, is free-radicaloxidation of lipids, chemiluminescence
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ТHE POSSIBILITY OF ULTRASOUND SONOGRAPHY AND 3D RECONSTRUCTION OF THE ABDOMINAL VESSELS IN PATIENTS WITH DIFFUSE LIVER DISEASES AND HEPATIC ENCEPHALOPATHY
Moiseeva E. O.
UDC: 616.831-073.48:616.36
Abstract: The article represents survey data from 155 patients (70 patients with diffuse liver disease and a manifestation of hepatic encephalopathy stage I-III and control group consisted of 85 patients with other diseases of the gastrointestinal tract. The etiology of disease is 41% patient of viral, 31% alcohol and 28% of mixed etiology. The advanced method of ultrasound diagnosis of hepatic encephalopathy and dopplerographic markers of vascular deformation v. portae in mode 3D in points are developed for early detection of changes in cerebral hemodynamics and staging of hepatic encephalopathy.
Key words: диффузные заболевания печени, печеночная энцефалопатия, ультразвуковая сонография, 3D-режим, diffuse liver diseases, hepatic encephalopathy, ultrasound sonography, 3D mode
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THE PATHOPHYSIOLOGICAL SUBSTANTIATION OF THE APPLICATION OF ELASTOGRAPHY IN PATIENTS WITH THE ALCOHOLIC LIVER DISEASE
Morozova T. G., Borsukov A. V.
UDC: 616.36-073.48:616.89-008.441.13
Abstract: The carried out the pathophysiological substantiation of the application of elastography in 20 patients with the alcoholic liver disease (ALD). According to the results of a study one should use elastography of the liver and spleen for monitoring of treatment, and also as the accessory criterion of diagnostics of the development of complications of ALD. Elastography of spleen increases the accuracy of diagnostics of the alcoholic liver disease both at the stage of severe fibrosis and with the light degree of fibrosis.
Key words: алкогольная болезнь печени, ультразвуковая эластография печени и селезенки, фиброз, alcoholic liver disease, ultrasound elastography of the liver and spleen, fibrosis
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ALCOHOLIC LIVER CIRROSIS: THE RISE OF THE EFFECTIVE THERAPY
Morozova T. G., Litvinova T. A., Denisova T.P.
UDC: 616.36-004.34-008.7+615.015
Abstract: This article covers the information of positive effect of discrete plasmapheresis in complex therapy of alcoholic cirrhosis. It is shown that discrete plasmapheresis improves patients’ state and functional liver samples. Discrete plasmapheresis may be widely adopted in application to clinical practice for increasing efficiency of standard basic therapy.
Key words: алкогольный цирроз печени, дискретный плазмаферез, alcoholic liver cirrhosis, discrete plasmapheresis
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MICROCIRCULATION AND VASCULAR-TISSUE PERMEABILITY IN GASTRIC MUCOUS IN PATIENTS WITH PEPTIC ULCER IN HELICOBACTER PYLORI PERSISTENCE
Nikitin G. A.
UDC: 616.33-002.44
Abstract: In patients with gastric ulcer disease the processes of microcirculation and vascular-tissue permeability of the gastric mucouse membrane are increased. They are combined with the changes of the stomach functions. Remission without eradication of Helicobacter pylori doesn’t result their complete recovery.
Key words: микроциркуляция, сосудисто-тканевая проницаемость, слизистая оболочка желудка, язвенная болезнь, microcirculation, vascular-tissue permeability, gastric mucouse membrane, gastric ulcer disease
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LACTASE INSUFFICIENCY AND ITS CORRECTION IN CHILDREN OF 1 YEAR AGE IN THE SMOLENSK CITY
Parmenova L. P., Ermachkova E. N.
UDC: 616.3-053.36 (470.332)
Abstract: Lactase insufficiency [LI] is the most common pathology of small intestine, characterized by development of the syndrome of maldigestion and malabsorbtion, related to absence or insufficient activity of the enzyme lactase. The purpose of this study is diagnostics of lactase insufficiency and assessment of effectiveness of the therapy with bioactive substance [BAS] “Lactazar for children”. Examination of 31 children of 1 to 7 months age with syndrome of prolonged diarrhea revealed average excretion of carbohydrates 1.2+/-0.3% (min 0.6 - max 2.0). Results of the study showed good tolerance and clinical effectiveness of BAS “Lactazar for children”, which allowed to preserve breast feeding in children with LI.
Key words: лактаза, лактазная недостаточность, диагностика, терапия, lactase, lactase insufficiency, diagnostics, therapy
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PRIOR RESULTS OF COMPARATIVE ASSESSMENT OF HEPATOPROTECTORS INFLUENCE ON LIVER CONDITION IN PATIENT WITH CHRONIC DIFFUSIVE LIVER DISEASES
Podoprigorova V. G., Bychkova E. V., Stepanova N. S., Kovaleva N. V., Ivanova A. V.
UDC: 616.36-004-073.48:615.015
Abstract: The article presents the comparative assessment of changes in the clinical and biochemical status under the treatment by various hepatoprotectors. The changes of sonographic parameters and parameters of bioradical status in patients with chronic liver diseases were also estimated before and after the treatment.
Key words: хронические диффузные заболевания печени, цитолиз, гепатопротекторы, ультразвуковое исследование органов брюшной полости, биорадикальные параметры, chronic diffusive liver diseases, cytolysis, hepatoprotector, ultrasonography digestive apparatus, bioradical parameters
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MYTHS AND REALITY OF PEPTIC ULCER DISEASE
Podcheko P. I.
UDC: 616. 33.- 002
Abstract: The peptic ulcer disease is presented in the modern scientific medical literature as the polietiologic, chronic, H. pylory - associated disease and disposed to exacerbations. It is stated that heartburn is one of the main symptoms of this disease. The author’s opinion, this conception and some others are not actual. In this article author provides evidence that peptic ulcer disease is a monocausative disorder caused by acidopeptic factor. The author also presents an alternative point of view on various aspects of peptic ulcer disease.
Key words: язвенная болезнь, этиология, ацидопептический фактор, альтернативные суждения, Peptic ulcer disease, etiology, acidopeptic factor, alternative hypothesis
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MELATONIN AND IT’S ROLE IN INTERNAL DISEASES CLINIC
Rapoport S. I.
UDC: 616.831.45:616.1/.4
Abstract: Melatonin plays a great role in different physiologic processes and organism functions. Seasonal exacerbations of internal diseases are exist and to be comlex process in which melatonin takes of no small importance. Numerous characteristics of melatonin allow hormone use in immunodeficiency states composite therapy both correction of elevated immune responsiveness.
Key words: мелатонин, эпифиз, адаптация, внутренние болезни, melatonin, epiphysis, adaptation, internal diseases
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INTESTINAL VIABILITY DETERMINATION IN MATTER OF EXPERIMENTAL BOWEL IMPASSABILITY WITH USE OF BIOIMPEDANSOMETRY
Rodin A. V., Leonov S. D.
UDC: 616.34-007.272.001.6
Abstract: It is presented an analysis of the dynamics of changes in impedance of the small and large intestine at various periods during acute intestinal and colonic obstruction in experiment. We identified the decrease of impedance values small and large intestine in comparison with the norm, indicating a progressive disorder of microcirculation in the small or large intestine, and its necrosis.
Key words: острая кишечная непроходимость, жизнеспособность кишечника, импеданс, intestinal obstruction, viability of the intestine, impedance
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THE INFLUENCE OF PEPTIC ULCER SEVERITY ASSOCIATED WITH H. PYLORI ON THE COURSE OF DISEASE AND WAY OF IT’S PREDICTION
Russiyanov V. V.
UDC: 616.33-002.44:615.73
Abstract: Influence of weight of a current of stomach ulcer on degree semination a mucous membrane of stomach Helicobacter pylori, resultsа eradication therapies, reinfection, relapses of disease and a condition of fractions of the free and connected water in biomacromolecules uniform elements of blood was studied. The way of forecasting of a current of disease on change of fractions of water is offered in biomacromolecules blood.
Key words: язвенная болезнь, тяжесть течения, Helicobacter pylori, эрадикационная терапия, состояние фракций воды в биомакромолекулах крови, stomach ulcer, weight of a current, Helicobacter pylori, eradication therapy, state of the water fractions in biomacromolecules blood
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ACUTE DESTRUCTIVE PANCREATITIS AS ACTUAL PROBLEM OF URGENT ABDOMINAL SURGERY
Skutova V.A., Abrosimov S.Yu., Chajkovsky Yu. A.
UDC: 616.37-002-089
Abstract: The article presents data of retrospective analysis of the tactics and methods of treatment in patients with acute destructive pancreatitis, who were admitted to the Clinical Emergency Hospital (Smolensk) during the period 2006 to 2008.
Key words: острый панкреатит, интенсивная терапия, операции при панкреонекрозе, acute pancreatitis, intensive care, surgical treatment of pancreonecrosis
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ORIGINAL COURSE OF PANCREATITIS ASSOCIATED WITH CHRONIC HEPATITIS
Udovikova O. I., Khibin L. S., Ivanichkina E. V., Stepanova N. S., Volk G. P., Russiyanova T. P.
UDC: 616.37-002:616.36-002
Abstract: Clinical case of pancreatitis unusual course in patient with chronic cholestatic hepatitis is described. Observation confirms need in all clinical data accounting in case of associated affection of GIT organs for diagnostic mistakes avoiding.
Key words: панкреатит, гепатит, клинические особенности сочетанного поражения, pancreatitis, hepatitis, clinical features of associated affection
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TO QUESTION OF GLUCOSE TOLERANCE TEST EFFICACY FOR LIVER FUNCTIONAL CONDITION DESCRIPTION IN CASE OF ITS TOXIC AFFECTION
Tishkova Ya. V., Molotkov O. V.
UDC: 616.36.002-099-07
Abstract: In dynamic of experimental toxic liver injury resulted from injection of carbon tetrachloride in a dose of 0,25 ml and 0,5 ml per 100 gr of weight to adult rats functional condition of the liver was investigated with glucose tolerance test. In these animals reduction of initial concentration of blood glucose and essential change glycimic waves were shown. Obtained findings indicate that glucose tolerance test was the informative for the investigation of liver function and makes possible to use its application to characterize the liver function in its toxic injury.
Key words: токсическое поражение печени, глюкозотолерантный тест, acute toxic liver injury, glucose tolerance test
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ERRORS IN PANCREATITIS DIAGNOSTICS
Khibin L. S., Udovikova O. I.
UDC: 616 37-002
Abstract: Pancreatitis is one of the causes of the death from alcochol disease. Descripe two letal causes from patients with alcochol disease and destruction pancreatitis. Pancreatitis no know earlier stage destruction pancreatitis- causes of the death.
Key words: алкогольная болезнь, панкреатит, alcoholic disease, pancreatitis
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STATUS OF UPPER GASTROINTESTINAL TRACT IN ACUTE STAGE OF PYELONEPHRITIS IN CHILDREN AND ADOLESCETS
Himova Yu. A., Pleshkova E. M.
UDC: 616.3:616.61-002.3-053.2
Abstract: Status of upper gastrointestinal tract was investigated in acute stage of pyelonephritis in 28 children and adolescents. Changes of gastrointestinal tract was appeied by ultrasonography in 57% patients. Changes of hepatobiliary system was appeied more frequаncy.
Key words: желудочно-кишечный тракт, дети, подростки, пиелонефрит, gastrointestinal tract, children, adolescents, pyelonephritiс
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AFFECTION OF ORAL AND TONGUE MUCOSA IN INDIVIDUALS WITH DISORDERS OF GASTROINTESTINAL TRACT
Tsepov L. M., Tsepova E. L.
UDC: 616.31-01.73-079.4
Abstract: In recent years, more attention is paid to the conditions with a combination of several diseases in one patient. Affection of oral and tongue mucosa is frequently found in individuals with disorders of gastrointestinal tract. The article reviews specific and unspecific changes of oral and tongue mucosa that are characteristics for main diseases of digestive system.
Key words: слизистая оболочка рта, язык, ротовая жидкость, пищеварительная система, oral mucosa, tongue, oral liquid, digestive system
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TRANSCRANIAL ELECTROSTIMULATION WITH FEEDBACK AS PREDICTION WAY OF LIVER CIRRHOSIS CLINICAL COURSE
Shulgan A.E.
UDC: 616.36-004+615.841
Abstract: Thirty patients aged from 30 to 60 years (mean age 46±2,15 years) with cirrhosis of different etiology and Child-Pugh degree of compensation were inspected. These patients have a sessions of electro stimulation of brain structures in addition to standard methods of research in liver cirrhosis. In the course of exploring the use of transcranial electrostimulation with feedback as a prognostic criterion for the clinical course of liver cirrhosis.
Key words: цирроз печени, транскраниальная электростимуляция, электроэнцефалограмма, cirrhosis, transcranial electrostimulation, electroencephalography
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ANTIOXIDANT PROTECTION STATE IN PATIENTS WITH CHRONIC HEPATITIS AND LIVER CIRRHOSIS IN AMBULATORY CONDITIONS
Yankovaya T. N.
UDC: 616.36-002.2:616.36-004+577.153
Abstract: In the given work the condition antioxidative protection in whey of blood at patients with a chronic hepatites and a cirrhosis of a liver was studied. Reduction of total antioxidizing activity and antioxidative systems сeruloplasming - transferring in whey of blood of patients especially expressed at patients with a cirrhosis of a liver has been revealed.
Key words: антиоксидантная система, церулоплазмин, трансферрин, хронический гепатит, цирроз печени, antioxidative system, сeruloplasming, transferring, chronic hepatites, cirrhosis of a liver
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PSYCHOTHERAPY OF PATIENTS WITH ISCHEMIC HEART DISEASE AND ANXIETY-DEPRESSIVE DISORDERS: GOALS, MISSIONS, POSSIBILITIES
Borokhova I. A., Borokhov A. V., Kozyrev O. A.
UDC: 616.12-009.72+615.851
Abstract: Anxiety-depressive disorders are prevalent in IHD patients. If these disorders are diagnosed in time cardiologists and physicians can treat the patients with psychotherapy only or with very low doses of antidepressants too. All cardiac rehabilitation programs include psychosocial interventions. Psychotherapeutic goals, missions and possibilities are present for cardiologists and physicians too.
Key words: психотерапия, ишемическая болезнь сердца, тревога депрессивные расстройства, psychotherapy, ischemic heart disease, anxiety-depressive disorders
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ANTIARRHYTHMIC EFFICACY OF AMIODARONE IN MAINTAINING SINUS RHYTHM IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION AND ATRIAL FLUTTER
Goryacheva A. A., Anfalova L.K.
UDC: 616.12-008.313.2-084+615.22
Abstract: The study evaluated prophylactic antiarrhythmic efficacy of amiodarone in maintaining sinus rhythm in patients with persistent atrial fibrillation (AF) and atrial flutter (AFL), depending on the nature of the underlying disease, duration and type of arrhythmia. After restoration of sinus rhythm electrical cardioversion (ECV) of 27 patients with AF and TA received amiodarone, the maintenance dose of 200 mg / day. Observation was made on clinical, ECG and ECG monitoring by Holter for 1 year. 1 year sinus rhythm was maintained in 46.2% of patients. There were no significant differences between groups by type of arrhythmia and the nature of the disease, although an earlier relapse was observed in patients with TA and coronary heart disease.
Key words: фибрилляция предсердий, трепетание предсердий, амиодарон, atrial fibrillation, atrial flutter, amiodarone
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PREVALENCE OF CYP2C9 AND VKORC1 GENETIC VARIANTS IN PATIENTS WITH ATRIAL FIBTILLATION IN SMOLENSK REGION
Korneva E. V., Rachina S. A., Milyagin V. A., Romanov A. V., Edel’shteyn M. V.
UDC: 616.12-008.313+615.015
Abstract: A total of 61 patients with atrial fibrillation in Smolensk region who needed warfarin therapy were included into the study, in which the detection of the variants of CYP2C9 and VKORC1 genes were provided. The prevalence of warfarin sensitivity genotypes was widespread in the study population.
Key words: варфарин, фармакогенетика, значимые полиморфизмы генов CYP2C9 и VKORC1, warfarin, pharmacogenetics, significant polymorphisms of CYP2C9 and VKORC1
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FEATURES OF DETERIORATION OF ENDOTHELIAL FUNCTION IN PATIENTS WITH UNSTABLE ANGINA
Kostenko O. V., Koroleva E. V.
UDC: 616.12-009.72
Abstract: Results of examination of 50 patients with unstable angina are discussed in this article. Research of endothelial function was performed to all patients. The condition of peripheral vessels was determined. The comparative analysis of the received results was carried out.
Key words: функция эндотелия, нестабильная стенокардия, атеросклеротическое поражение сосудов, unstable angina, endothelial function, atherosclerotic deterioration of vessels
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ARTERIAL HYPERTENSION IN STUDENTS OF SMOLENSK
Legon'kova A. S.
UDC: 616.12-008.331.1 (470.332)
Abstract: Article describes the results of the study, that was led to determine the spread of arterial hypertension in youth 16-22 years old, studying in institutions in Smolensk. The blood pressure was estimated by GP-303s device, anthropometrics and risk factors for cardiovascular disease were also determined in the investigation.
Key words: артериальная гипертония, лица молодого возраста, факторы риска, arterial hypertension, young people, risk factors
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THE ROLE OF THE EARLY REMODELING OF ARTERIAL WALLS IN A PATHOGENESIS OF ARTERIAL HYPERTENSION IN YOUNG PATIENTS
Leksina Yu. N.
UDC: 616.12-008.331. 1-053.84
Abstract: The article describes the results of the investigation on the vascular remodeling in a pathogenesis of arterial hypertension in young patients. The dependence between the stiffness of muscular and elastic vessels and levels of arterial pressure on hands and legs in patients with systolodiastolic arterial hypertension is shown in this report.
Key words: cистоло-диастолическая артериальная гипертензия, ремоделирование сосудов, скорость пульсовой волны, индекс жесткости CAVI, systolodiastolic arterial hypertension, vascular remodeling, stiffness of muscular and elastic vessels
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A CASE OF SECONDARY INFECTIOUS ENDOCARDITIS AGAINST THE BACKDROP OF THE ELECTRODE ENDOCARDITIS IN THE PATIENT AFTER IMPLANTATION OF CARDIOSTIMULATOR
Litvinova I. A., Zubkov S. K., Denisova T. P., Morozova T. G.
UDC: 616.126-002-07
Abstract: Infective endocarditis (IE) is a disease with persistent high mortality rate, which has not significantly changed over the past decade, despite the progress of visualizing diagnostic examinations, antibacterial therapy and surgical treatment.
Key words: возбудители, инфекционный эндокардит, клинические особенности, предрасполагающие факторы, эволюция, pathogens, infective endocarditis, clinical features, predisposing factors, evolution
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THE ANALYSIS OF KNOWLEDGE OF PATIENTS OF CARDIOLOGICAL BRANCHES ABOUT RISK FACTORS OF CARDIOVASCULAR DISEASES AND AN ESTIMATION THERAPIES AT A PRE-HOSPITAL STAGE
Litvinova I. A., Morozova T. G., Zubkov S. K.
UDC: 616.12
Abstract: Cardiovascular diseases fairly name epidemic of the XX-th century which, unfortunately, proceeds and in the XXI-st century. Within several decades they are a leading cause of death of the population in industrially developed countries, including in Russia where cardiovascular diseases fairly from annually die about 1 million 200 thousand persons (about 55% of the general death rate).
Key words: сердечно-сосудистые заболевания, факторы риска, терапия, лечение, профилактика, cardiovascular diseases, risk factors, therapy, treatment, preventive maintenance
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KNOWLEDGE OF ADULT POPULATION OF SMOLENSK OF RISK FACTORS OF CARDIOVASCULAR DISEASES
Litvinova I. A.
UDC: 616.12
Abstract: To analyse knowledge of adult population of Smolensk of risk factors cardiovascular diseases which can be partially modified.
Key words: сердце, факторы риска, артериальная гипертензия, гиперхолестеринемия, коррекция, heart, risk factors, an arterial hypertensia, a hypercholesterolemia, correction
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INFLUENCE OF REPERFUSION THERAPY FOR DEVELOPMENT OF DECOMPENSATION OF CARDIOVASCULAR SYSTEM DURING THE FIRST YEAR AFTER A MYOCARDIAL INFARCTION
Prakopchik I. V.
UDC: 616.127-005.8
Abstract: This article contents information about influence of reperfusion therapy for development of decompensation of cardiovascular system during the first year after a myocardial infarction. There are no found differences between groups of patients who received and not affected by this treatment.
Key words: инфаркт миокарда, тромболизис, прогноз, myocardial infarction, fibrinolysis, forecast
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ARTERIAL STIFFNESS AS A PREDICTOR OF CORONARY HEART DISEASE AFFECTION
Purygina M. A., Kokhonova O. P., Milyagin V.A., Kozlov A.V.
UDC: 616.12-005.4
Abstract: Article shows the results of the investigation on the arterial stiffness in patients after coronaroangiography, that was measured by methods of volumetric sphygmography and applanation tonometry.
Key words: скорость распространения пульсовой волны, индекс жесткости CAVI и kCAVI, центральное (аортальное) АД, атеросклероз, коронароангиография, pulse wave velocity, cardio-ankle vascular index, central blood pressure, atherosclerosis, coronaroangiography
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HEART RATE VARIABILITY IN PATIENTS WITH CHRONIC HEART FAILURE
Semionenkova N.V., Marshutin N.A., Novikova T.A.
UDC: 616.12-008.46
Abstract: In the article are given the results of the examination of 20 patients of 32-72 years old before and after mild physical activity. All the patients had ischemic heart disease and heart failure of functional class II. 12 patients of 20-26 years old without heart disease were observed as control group. Both groups of patients were tested using pulse photoplethysmography by «BioMouse» of the «NeuroLab» company. Low value of SDNN (standard deviation of all NN-intervals) was registered in patients with heart failure before (33,25±2,70 ms vs) and after (35,75±3,02 ms vs) walking. RMSSD (the square root of the mean value of the sum of the squares of differences between adjacent NN-intervals) was lower in patients with heart failure only before walking. Value of HF (high frequency) decreased in patients with heart failure after walking. Such the changes were discussed as the signs of pathologic sympathycus stimulation and should be taken into account in the assessment of health status of patients with heart failure.
Key words: вариабельность сердечного ритма, сердечная недостаточность, ишемическая болезнь сердца, пульсовая фотоплетизмография, heart rate variability, heart failure, ischemic heart disease, pulse photoplethysmography
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HYPERHOMOCYSTEINEMIA ROLE IN DEVELOPMENT OF ISCHEMIC HEART DISEASE
Sosina O. Yu., Kozyrev O. A.
UDC: 616.12-009.72-055.1
Abstract: Epidemiological features of hyperhomocysteinemia, interrelation between hyperhomocysteinemia and atherosclerotic changes of peripheral arteries were studied. High levels of total homocysteine as independent risk factor of atherosclerosis at patients with ischemic heart disease were demonstrated.
Key words: гомоцистеин, гипергомоцистеинемия, атеросклероз, ишемическая болезнь сердца, homocysteine, hyperhomocysteinemia, atherosclerosis, ischemic heart disease
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CLINICALLY NOT RECOGNIZED INFECTIOUS ENDOCARDITIS
Udovikova O. I., Ivanishkina E. V., Khibin L. S., Stepanova N. S., Prudnikova N. V., Petrochenkova L. A.
UDC: 616.126-002-071-08
Abstract: The statistical data confirming growth of disease infectious endocarditis, high mortality are cited at the given pathology. It is paid attention to difficulties in recognition infectious endocarditis. Clinical supervision not verified during lifetime of infectious endocarditis is described.
Key words: инфекционный эндокардит, трудности диагностики, клиническое течение, infectious endocarditis, difficulties of diagnostics, clinical course
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TREATMENT OF PATIENTS WITH ACUTE CORONARY SYNDROMES IN HOSPITAL WITHOUT POSSIBILITIES TO PERFORM INVASIVE CORONARY PROCEDURES
Khokhlova Yu. A., Kozyrev O. A., Frolkova O. O.
UDC: 616.12-005.4-08
Abstract: The management strategy is analyzed at 190 patients with coronary syndromes with ST segment elevation and 389 patients with coronary syndromes without ST segment elevation of cardiology departments the Smolensk’s emergency hospital. Inhospital mortality patients with coronary syndromes with ST segment elevation was 17,99%, patients with coronary syndromes without ST segment elevation - 5,09%. Thrombolytic therapy was used only in 18,42% of patients with coronary syndromes with ST segment elevation. According to results of the research we are recommended respect to modern guidelines for the management of patients with coronary syndromes with/without ST segment elevation, use to widely thrombolytic therapy, low-molecular-weight heparin, modern antiplatelet, hypolipidemic drugs and beta-blockers.
Key words: острый коронарный синдром без подъема сегмента ST, острый коронарный синдром c подъемом сегмента ST, тромболитическая терапия, тактика лечения, acute coronary syndromes without ST segment elevation, acute coronary syndromes with ST segment elevation, thrombolytic therapy, management strategies
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FEATURES OF CURRENT RHEUMATOID ARTHRITIS ACCORDING TO DATA OF RHEUMATOLOGIC CENTRE
Bazina I. B., Pavlova M. V., Semchenkova M. Yu., Mazhaeva O. S.
UDC: 616.72-002.77
Abstract: This article contains results of examination of 223 patients with rheumatoid arthritis, which were treated in Rheumatologic Centre of Smolensk hospital of « Russian railways ». Women - 82,3%, men - 17,7%. Patients of young age - 10,3%. The most frequent complication was synovite of average and small joints (30,9%).Seropositive rheumatoid arthritis has been revealed at 89,6% of patients. Nonerosive rheumatoid arthritis was defined at 11,6% of patients, erosive - at 88,4%. Accompanying diseases included ischemic heart disease (37,7%) and arterial hypertension (57,9%).Basic therapy of patients consisted of Metotreksat from 2,5 up to 15 mg/weeks (65%); Leflunamid 20 mg/day (2,2%), Sulfasalazin (5,8%). 4,5% of patients did not receive basic therapy. Tumor necrosis factor inhibition didn’t use for treatment because of high price of medicines.
Key words: ревматоидный артрит, атеросклероз, ИБС, АГ, метотрексат, ингибиторы ФНО-α, rheumatoid arthritis, atherosclerosis, ischemic heart disease, arterial hypertension, metotreksat, tumor necrosis factor inhibition
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CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND COMORBIDITIES
Denisova T. P., Morozova T. G., Litvinova I. A.
UDC: 616.24-036.12:616
Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a disease with some significant extrapulmonary effects. Retrospective analysis is carried out at 62 histories of patients with COPD. According to results of research COPD is associated with arterial hypertension, arrhythmias, hypercholesterolemia, ulcers of stomach or duodenum, chronic pyelonephritis.
Key words: ХОБЛ, сопутствующая патология, системные проявления, COPD, comorbidities, extrapulmonary effects
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VALUATION THE QUESTIONNAIRES IN CONTROL LEVEL OF BRONCHIAL ASTHMA
Zakharova Yu. V., Punin A. A.
UDC: 616.248:612.017.1
Abstract: The purpose of this study was to compare the efficiency of various questionnaires in patients with persistent bronchial asthma in real clinical practice. 215 subjects with a different asthma per GINA 2006 took part in the study. Criteria E. Bateman, GOAL and Asthma Control Test were study.
Key words: бронхиальная астма, контроль, вопросники, bronchial asthma, control, questionnaires
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SPECTRUM OF MICROORGANISMS IN THE SPUTUM OF COPD PATIENTS WITH SEVERE COURSE AND THEIR SENSITIVITY TO ANTIBIOTICS
Karpova O. N., Punin A. A., Krechikova O. I.
UDC: 616.24:615.33
Abstract: Bacteriological examination of sputum 117 patients with severe acute exacerbation of COPD and moderate current study the spectrum of the main microorganisms and their sensitivity to antibiotics. The most frequent organism was H. Influenzae. Considering the data obtained from the spectrum of sensitivity for the empirical treatment of COPD exacerbations, first-line drugs may be amoxicillin / clavulanate and levofloxacin.
Key words: ХОБЛ, антибактериальная терапия, COPD, antibiotic therapy
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СHRONIC ALCOHOLIC INTOXICATION AND DEVELOPMENT OF POOR OUTCOME IN THE PATIENTS OF MULTI-FIELD MUNICIPAL HOSPITAL
Korolyeva E. V., Kostenko O. V.
UDC: 616.24-002:613.81
Abstract: The analysis demographic, clinical and laboratory parameters of the patients who have died of pneumonia, studying of autopsy reports, considering criteria of a chronic alcoholic intoxication are discussed in this article.
Key words: пневмония, хроническая алкогольная интоксикация, pneumonia, chronic alcoholic intoxication
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SPECIFIC FEATHERS OF PNEUMONIA ASSOCIATED WITH FLU H1N1 IN SMOLENSK
Molotkov A. O., Punin A. A., Evseeva I. P., Gulyaeva S. A., Pikalova O. S., Doroginin S. V.
UDC: 616.24-002:616.921.5(470.332)
Abstract: In work materials of 328 case records of patients with flu H1N1, the virus-bacterial and bacterial pneumonia, were on treatment in МЛПУ ГКБN1 of Smolensk from October, 2009 till February, 2010 are analyzed. Increase of frequency of pneumonia, cases of development ARDS and lethality among young and average age group, and as at pregnant women in time epidemic of «pork» flu is revealed.
Key words: грипп H1N1, пневмония, flu H1N1, pneumonia
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ANALYSIS OF ANTIBIOTIC THERAPY OF OUTPATIENT IN HOSPITALIZED PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA
Shelyakina O. G.
UDC: 616.24-002+615.33
Abstract: A total of 50 patients with community-acquired pneumonia, hospitalized in Pulmonology at the age of 22 to 84 years (mean age 49±16,1 years). During the previous hospitalization was studied antibacterial therapy. The findings suggest how to improve drug therapy of community acquired pneumonia in the outpatient as well as about the existence of problems in the treatment of these patients.
Key words: внебольничная пневмония, антибактериальная терапия, community-acquired pneumonia, antimicrobial therapy
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HISTOLOGICAL AND MICROBIOLOGICAL DIAGNOSTICS OF INFECTION: RESULTS OF LOCAL STUDY
Dekhnich N. N., Kostyakova T. A., Alimov A. V., Ivanchik N. V.
UDC: 616.3-078.33-018
Abstract: Overall 210 adult patients with H. pylori -associated diseases with positive results of rapid urease test were included in the study in 2009-2010 in Smolensk. Histological finding appeared to be informative in 179 enrolled patients. Among them detection of H. pylori - infection was revealed by means of histological method in 124 patients (69,3%), of microbiological method - in 116 patients (64,8%). Histological and microbiological confirmation of H. pylori - infection was received in 83 patients (46,4%). In 124 patients with histological confirmation lack of H.pylori -growth by plating of biopsy specimens was registered in 33% patients (n=41). In 116 patients with microbiological confirmation negative histological finding was registered in 28,4% patients (n=33).
Key words: Helicobacter pylori, гистологический метод, микробиологический метод, Helicobacter pylori, histological method, microbiological method
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GASTROINTESTINAL SYMPTOMS ARE THE SOMATIC PATHOLOGY MARKER IN PREGNANT WOMEN
Konyshko N. A.
UDC: 618.3-007.17
Abstract: Several symptoms have been hypothesized to influence the risk of preeclampsia. Our aim in this study was to estimate the association between gastrointestinal patterns during pregnancy and the risk of gastritis, ulcer disease, preeclampsia, obesity and arterial hypertension in pregnant women. Women participating in study answered questionnaires. Exploratory factor analysis was used to assess the associations among variables. Principal component factor analysis identified 12 primary gastrointestinal patterns that were labeled: epigastric pain and dyspepsia. Relative risks of gastritis, preeclampsia, arterial hypertension were estimated as odds ratios (OR) and confounder control was performed with multiple logistic regression. Women with high scores on a pattern characterized by pain nausea, vomiting, disrexia, asthenic syndrome, constipation. These findings suggest that a dietary pattern characterized by high intake of vegetables, plant foods, increases the risk of dyspeptic disorders, whereas a medicines pattern characterized by high consumption of processed increases the risk.
Key words: беременность, гастроинтестинальная патология, гестоз, артериальная гипертензия, gastrointestinal patterns, pregnancy, preeclampsia, arterial hypertension
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CHANGES OF INDICATORS OF THE PSYCHOLOGICAL STATUS IN PATIENTS WITH DUODENAL ULCER
Shkitin V.A., Panisyak N.A.
UDC: 616.342-002.44
Abstract: Increasing of anxiety and depression level during exacerbation of duodenal ulcer was revealed. Under the influence of treatment positive dynamics was marked, but without normalization of the indicators. More expressed abnormalities of indicators of the psychological status were found in women group, especially with physical work, and persons from the senior age group. The least level of anxiety and depression among men was observed in a nonsmoking subgroup.
Key words: язвенная болезнь, психологический статус, тревожность, депрессия, stomach ulcer, psychological status, anxiety, depression
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CLUSTER ANALYSIS OF QUALITY OF LIFE AND PSYCHOLOGICAL STATUS INDICATORS IN PATIENTS WITH DUODENAL ULCER
Shkitin V.A., Panisyak N.A.
UDC: 616.342-002.44
Abstract: The highest indicators of quality of life were observed in groups with low level of anxiety and depression. All indicators of quality of life were significantly decreased in case of expressed change of a psychological condition. Considering that in group of patients with high level of anxiety and depression was defined low degree of quality of life, it demands referral of this category of the patients to the psychotherapist.
Key words: язвенная болезнь, качество жизни, психосоматика, психологический статус, stomach ulcer, quality of life, psychosomatics, the psychological status
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