CONJUGATION IN ACTIVITY OF GABA- AND DOPAMINERGIC MECHANISMS OF THE BED NUCLEUS OF STRIA TERMINALIS IN SUPPLY OF THE REINFORCING EFFECTS OF PSYCHOTROPIC DRUGS
Shabanov P.D., Lebedev A.A.
UDC: 612.82:615.78+569.324.3
Abstract: The purpose of the investigation was to clear up the significance of GABA and dopamine systems of the bed nucleus of stria terminalis for the reinforcing effects of a number of psychotropic drugs (opiates, opioids, psychostimulants) on self-stimulation of the lateral hypothalamus in rats. The Wistar male rats were implanted bipolar electrodes in the lateral hypothalamus to study self-stimulation reaction in the Skinner box. Simultaneously, the microcannules were implanted into the bed nucleus of stria terminalis to inject the drugs studied (1 μg in 1 μl in volume for each injection). Some drugs, xycaine, or lidocain, a blocker of sodium influx ionic currents, antagonists of GABA receptors bicuculline, D dopamine receptors SCH23390 and D dopamine receptors sulpiride, which were administered intrastructurally into the bed nucleus of stria terminalis, were used for pharmacological analysis. Xycaine > SCH23390 ≈ bicuculline (the drugs are located in the range of descending inhibition activity) inhibited self-stimulation of the lateral hypothalamus. The reinforcing properties of a number of psychoactive drugs (amphetamine, fentanyl, sodium ethaminal and leu-enkephaline) were changed on the background of their action. It is concludeed that the bed nucleus of stria terminalis controls the hypothalamic self-stimulation via GABA- and dopaminergic mechanisms. GABA realizes the negative (inhibitory) action. The direct positive (activating) effect on the lateral hypothalamus is realized through D dopamine receptors, and D dopamine receptors of the bed nucleus of stria terminalis limit the positive effects of narcogenic drugs.
Key words: ГАМК, дофамин, ядро ложа конечной полоски, самостимуляция мозга, латеральный гипоталамус, бикукуллин, лидокаин, сульпирид, SCH23390, фенамин, фентанил, этаминал-натрий, лей-энкефалин, GABA, dopamine, bed nucleus of stria terminalis, self-stimulation, lateral hypothalamus, bicuculline, xycaine, sulpiride, SCH23390, amphetamine, fentanyl, sodium ethaminal, leu-enkephaline
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EARLY MANIFESTATUIONS OF METABOLIC DISODERS IN ARTERIAL HYPERTENSION TEENAGERS
Belyaeva L.M., Korol S.M., Voitova E.V., Matyushko T.S., Chizhevskaya I.D.
UDC: 616.12-008.331.1-053.2-056.52-036.1-008.9
Abstract: The article discloses causes of arterial hypertension, its clinical manifestations and prophylaxis in teenagers. The study contucted has found decrease of alpha-cholesterol content, increase of both low-density lipoproteins and quotient of atherogeneity in comparison with healthy teenagers. The majority of teenagers with stable arterial hypertension have insulin resistance. High blood serum cortisol level is detected in all clinical groups of patients with dyslipidemia and insulin resistance that may be considered as additional signs of metabolic syndrome.
Key words: артериальная гипертензия, подростки, метаболические нарушения, arterial hypertension, teenagers, metabolic disorders
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OXIDATIVE STATUS CHARACTERISTICS OF NEWBORNS WITH CNS HYPOXIC INJURIES AND METHODS OF PEROXIDATION PROCESS CORRECTION
Bekezin V.V., Kozlova L.V., Fedorov G.N., Peresetskaya O.V.
UDC: 616.83-001.8-053.31-08
Abstract: The article presents results of free-radicals oxidation processes determination by the chemiluminescence method in blood plasma of newborn infants suffering with cerebral ischemia. Recommendations for therapy performed in different age groups, taking into consideration oxidative status and different stage of brain hypoxia have been designed
Key words: окислительный статус, новорожденные, гипоксия, мозг, коррекция, oxidative status, newborn infants, hypoxia, brain, correction
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PRACTICAL ASPECTS OF MODERN DIETETICS IN PEDIATRICS
Legonkova T.I., Matveyeva E.V., Stepina T.G., Makarova V.N.
UDC: 612.653:613.953.1+616-053.31
Abstract: In the article the results of complex comparison between physical condition of first-year infants and their neurologic-and-behavioral maturation, morbidity, immune status, occurrence of functional digestion disorders and intestine microbiocoenosis in depending of feeding type are discussed in detail. It has been established that occurrence of CNS structural changes, subsequent improvement of both brain parenchyma and thalamus echo-structure, decrease of both lateral ventricles changes and outer liquor spaces, decrease of hypoxic-ischemic changes are really lower in infants received breast milk feeding and the high-adaptive feeding mixture in comparison with infants received the standard mixture.
Key words: дети 1-го года жизни, вскармливание, ЦНС, гипоксия, ишемия, first-year infants, feeding, CNS, hypoxia, ischemia
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ACUTE TOXICITIES OF SELENIUM-CONTAINING METAL-COMPLEX SUBSTANCES WITH HIGH ACTIVITIES IN ACUTE EXOGENOUS HYPOXIA
Sosin D.V., Yevseyev A.V.
UDC: 616-001.8:615.9:546.23+612.273
Abstract: The article is devoted to the results of both acute toxicities and safety determination of selenium-containing metal-complex substances πQ1983, πQ2170 that have high pharmacological activities in acute exogenous hypoxia after their introperitoneal or enteral introductions in mice. According to established parameters LD the couple of studied substances can be referred to the category of high toxic chemical agents. However, the substance πQ1983 can be recommended for its preclinical investigation because it has rather permissible parameters of ED and therapeutic indexes.
Key words: металлокомплексные антигипоксанты, острая токсичность, эффективность, терапевтический индекс, мыши, metal complex substances, acute toxicity, activity, therapeutic index, mice
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INFLUENCE OF ANTIHYPOXANTS ON ACETYLSALICYLIC ACID EFFICIENCY IN ACUTE INFLAMMATION
Ilyukhin S.A., Novikov V.E.
UDC: 615.015.21:615.276
Abstract: During the experiment, rats were injected 0, 1 ml of 1% solution of carragenin subplantarly. De development of an acute inflammatory reaction has been observed. It was manifested like swelling of the limbs, neutrophilic leukocytosis, increased erythrocyte sedimentation rate), which was formed after 3 hours and persisted for 30 days. Acetylsalicylic acid in dose of 100 mg/kg reduced the development of the inflammatory response. Antihypoxants (hypoxen, metaprot, amtizol, hesperidin) in dose of 50 mg/kg had different effects on the development of an acute inflammatory response. Hypoxen and metaprot has a slight anti-inflammatory effect, and ina joint enteral administration with ASA potentiated its anti-inflammatory effect, which manifested significant reduction of reported indicators of inflammation. Amtizol and hesperedin did not have a marked influence on the development of an acute inflammatory response.
Key words: Антигипоксанты, кислота ацетилсалициловая, каррагенин, острое воспаление, antihypoxants, acetylsalicylic acid, carragenin, acute inflammation
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COMPARATIVE STUDY OF TRANSDERMAL HYPOXEN PLASTER TOXICITY
Losenkova S.O., Fyodorov G.N., Stepanova E.F., Geraskina A.P.
UDC: 615.9:615.416:616-001.8-074
Abstract: It is spent preclinical safety studying transdermal a plaster with hypoxen. Introduction transdermal of hypoxen to rats within a month in doses 75-1500 mg/кg does not cause destruction of animals. Application of damaging doses 600-1500 mg/кg results to decrease a lump gain, to change of behavioral reactions, infringement of function of kidneys, and also development of the nonlethal pathological changes from the party blooding bodies of rats.
Key words: гипоксен, трансдермальный пластырь, субхроническая токсичность, hypoxen, transdermal plaster, subchronic toxicity
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THE MOST COMMON LABORATORY ANTIBIOTICS RESEARCH METHODS
Farashchuk N.F., Tsyuman Yu.P.
UDC: 615.779.9-07
Abstract: The article is a review on modern laboratory methods of the qualitative and quantitative analysis of antibacterials, their efficiency and equivalence. Advantages and disadvantages as well as technological features of the applied methods are considered.
Key words: антибиотики, лабораторный анализ, качество, эффективность, antibiotics, laboratory analysis, quality, efficiency
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THE POSSIBILITIES OF THE THERAPY OF ANXIETY DISORDERS IN GENERAL MEDICAL PRACTICE: PROJECTS OF THE USE OF UNBENZODIAZEPINE ANXIOLYTIC AFOBAZOLE (REVIEW)
Semionenkova N.V., Argunova I.A.
UDC: 616.89-008.441.1+615.768
Abstract: In the review a wide-spread of affective disorders requiring the necessity of treatment of patients in General Medical Care is underlined. Current information on the use of native anxiolytic afobazole in general practice has been summed up. Comparative evaluation of the drugs with anxiolytic effect has been provided. The data on the structure, pharmacodynamic effect, indications for the administration and safety of afobazole are given. Attention is paid to the clinical studies of afobazole. The advantage of the treatment of anxiety disorders with afobazole in somatic patients is stated. There have been shown the possibilities of the use of this drug by general practitioners in out-patient depertaments
Key words: общая врачебная практика, тревожное расстройство, депрессия, анксиолитик, антидепрессант, general practice, anxiety disorder, depression, anxiolytic, antidepressant
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ENDOSCOPIC MUCOSAL RESECTION OF THE LARGE INTESTINE WITH ADENOMAS OF HIGH MALIGNIZATION RISK AS AN ALTERNATIVE TO THE BOWEL RESECTION
Zenzin A.V., Mihalik D.S., Pavlov A.A.
UDC: 616.345-006.03-072.1
Abstract: Large intestine adenomas have a high risk of rapid growth (increase in size) and oncological regeneration. Therefore, clinical management in case of this precancerous condition is unique, and is represented by endoscopic polypectomy. In case of a high risk of adenomas malignization surgical interference issue is especially urgent: resection of the large intestine vs. minimally invasive surgery. This article represents еndoscopic mucosal resection of the large intestine with adenomas of high malignization risk as an alternative to the bowel resection.
Key words: толстый кишечник, аденома, полипэктомия, малигнизация, large intestine, adenoma, polypectomy, malignization
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SEASONALITY OF ALLERGIC DISEASES AS A FACTOR INFLUENCING THE RETAIL SALES OF ANTIHISTAMINE REMEDIES (SMOLENSK)
Krikova A.V., Ostashuk M.S.
UDC: 615.218.2(470.332):616-053.3
Abstract: Pharmaceutical market of antihistamine remedies is characterized by pronounced seasonality due to the fact that in the spring-summer time the number of potential allergens (pollen, insects, the active sun, dust, etc.) became increased. It should be considered for the timely prevention of allergic diseases.
Key words: аллергические заболевания, антигистаминные препараты, сезонность, allergic diseases, antihistamine remedies, seasonality
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THE PROJECT OF ELASTOGRAPHY IN PATIENTS WITH MALIGNANT BREAST TUMORS
Solovev V.I., Borsukov A.V., Safronova M.A.
UDC: 616-006.04-08-039.75
Abstract: In the prospective group patients sent to oncology dispensary with suspected breast cancer for both further examination and decision for further treatment tactics have been included. In addition to the standard set of survey, mammography, axillography, ultrasound studies were included: breast sonoelastography, lymph nodes sonoelastography, and minimally invasive bioimpedance
Key words: соноэластография, рак молочной железы, малоинвазивная биоимпедансометрия, sonoelastography, breast cancer, miniinvasive bioimpedance
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MODERN APPROACHES TO TREATMENT OF GULLET CANCER
Zuj V.S., Solovyev V.I.
UDC: 616-006.04-08-039.75
Abstract: In practical medical institutions thanks to results of anesthesiology of resuscitation various surgical methods of treatment have more widely started to be applied at malignant tumors of a gullet thanks to what oncologists have the right to define the most expedient surgical approach to treatment of the given pathology. X-ray therapy is a choice method in strictly regulated indications.
Key words: рак пищевода, радикальное лечение, паллиативное лечение, симптоматическое лечение, gullet cancer, radical treatment, palliative treatment, symptomatic treatment
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ROLE OF FECAL CALPROTECTIN IN DIFFERENTIATING OF INTESTINAL PATHOLOGY
Mikhalik D.S., Zhukov G.V., Vishnevsky S.E., Nikolaenkova L.I., Syomchenkova M.J., Pogodina M.V., Maximenkova V.V.
UDC: 616.345-002-07
Abstract: The authors describe possibility of differential diagnostics of inflammatory intestinal diseases using a new marker - fecal calprotectin - and indications for further instrumental examination of bowels.
Key words: кальпротектин, толстый кишечник, воспаление, дифференциальная диагностика, calprotectin, large intestine, inflammation, differential diagnostics
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NEUROOPHTHALMOLOGIC COMPONENT OF CLINIC AND DIAGNOSTICS DEMYELINATING DISEASES
Maslova N.N., Andreeva E.A.
UDC: 616.832-004.2:617.7
Abstract: Multiple sclerosis is the most widespread demyelinating disease of the CNS affecting persons of young age. A violation visual function develops at 90% of patients with MS. In article it is pointed to interrelation of an optical neuritis with CNS pathology, methods of diagnostics of visual violations at demyelinating diseases.
Key words: рассеянный склероз, оптический неврит, диагностика, multiple sclerosis, optical neuritis, diagnostics
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DIDACTIC RESOURCES IN THE PROCESS OF FOREIGN LANGUAGE INSTRUCTION IN HIGHER MEDICAL SCHOOLS
Omelich O.K.
UDC: 42-07:61(071.1)
Abstract: The article is devoted to the opportunities of increasing the quality of teaching a foreign language. It is proposed to introduce specially selected proverbs into educational material for creating enthusiasm both at the beginning and at the end of a lesson as well as for teaching grammar and students’ vocabulary enrichment. Proverbs containing most important words and grammar structures useful for development of communicative competence have been selected. Some thoroughly tested ideas concerning activities for practical use of proverbs in communication are presented.
Key words: обучение, знания, темы, грамматический материал, усвоение, education, knowledge, topics, grammar material, memorizing
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