IMPACT OF HYPOXENS AND NSAIDS ON STRUCTURAL AND FUNCTIONAL STATE OF THE POPLITEAL LYMPH NODES IN ACUTE INFLAMMATION
Ilyukhin S.A., Platonov I.A., Novikov V.E.
UDC: 615.015.21:615.276
Abstract: Results of the study of the limbs and features of morphological and functional changes in the left popliteal lymph node in rats at 1, 7, 14 and 30 days in carrageenan-induced inflammation and pharmacological correction of antihypoxant hypoxen and anti-inflammatory drugs – acetylsalicylic acid and diclofenac have been presented in the study. It has been found out that hypoxen in combination with aspirin or diclofenac provides the most effective results reducing the size of a limb, course and severity of inflammation as well as structural and functional changes in the popliteal lymph node.
Key words: гипоксен, нестероидные противовоспалительные средства, морфометрия, подколенные лимфатические узлы, острое воспаление, hypoxen, non-steroidal anti-inflammatory drugs, morphometry, popliteal lymph nodes, acute inflammation
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IMPACT OF A SELENIUM-CONTAINING METAL-COMPLEX SUBSTANCE ΠQ1983 ON ELECTRICAL ACTIVITY OF MYOCARDIUM IN ACUTE HYPOXIA IN EXPERIMENTAL RATS
Sosin D.V., Evseyev A.V., Pravdivtsev V.A., Evseyeva M.A.
UDC: 616.273.015.3.08
Abstract: Changes in electrical activities of myocardium have been studied in oral introduction of a new selenium-containing metal-complex substance πQ1983 in dose 100 mg/kg before and after acute hypercapnic hypoxia (AH+Hc) development. A substance for comparison – metabolic antihypoxant amthizole was used by same way and dose. The substances were introduced 90 min before (incubation period) placing of animals into hypoxic chambers with 1.0 L free volume. ECG was recorded continually during both an incubation period and a hypoxic experiment. It has been established that the inhibitory action of the substance πQ1983 on electrical activity of myocardium looks like severe bradycardia. According to ECG data, rats protected with substance πQ1983 demonstrate the resistance level to the AH+Hc higher than ones that intake the antihypoxant amthizole. It has been proved by peculiarities of early myocardial hypercapnic reactions, parameters of lifespan, and length of a so called relative wellbeing period
Key words: крыса, острая гипоксия, гиперкапния, антигипоксанты, ЭКГ, миокард, rat, acute hypoxia, hypercapnia, antihypoxants, ECG, myocardium
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INFLUENCE OF PIOGLITAZONE AND ATORVASTATIN USE ON ADIPOKINE PROFILE AND INSULIN RESISTANCE IN ABDOMINALLY OBESE PATIENTS FOLLOWING ISCHEMIC ATHEROTHROMBOTIC HEMISPHERIC STROKE
Delva M.Yu., Lytvynenko N.V.
UDC: 616.831-005.1-056.5
Abstract: Effects of post-stroke intake of pioglitazone (30 mg daily) and atorvastatin (20 or 40 mg per day) for 90 days on adipokine profile and insulin resistance in abdominally obese (class 2 obesity) patients with acute ischemic atherothrombotic hemispheric stroke have been studied. Pioglitazone use was associated with significant increase in circulating adiponectin on 10 day (49.3±2.6 mg/ml vs 34.0±2.8 mg/ml in the control group, p<0.05) and on 90 day after stroke (53.8±2.2 mg/ml vs 42.5±3.8 mg/ml, respectively, p<0.05). Moreover, pioglitazone led to significant decrease in insulin resistance index HOMA-IR on 10 day (1.23±0.37 vs 2.10±0,26 in the control group, p<0.05) and on the 90 day after stroke (1.40±0.35 vs 3.06±0.45, respectively, p<0.05). Whereas, atorvastatin intake, regardless of the daily dosage, did not affect the adipokine profile and insulin resistance.
Key words: ишемический атеротромботический инсульт, абдоминальное ожирение, аторвастатин, пиоглитазон, адипонектин, лептин, инсулинорезистентность, ischemic atherothrombotic stroke, abdominal obesity, atorvastatin, pioglitazone, adiponectin, leptin, insulin resistance
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DAILY MONITORING OF BLOOD GLUCOSE ITO ASSESS COMPENSATION OF CARBOHYDRATE METABOLISM IN CHILDREN AND TEENAGERS WITH TYPE 1 DIABETES
Demyanenko A.N., Alimova I.L.
UDC: 616.379-008.64-053.2
Abstract: The study demonstrates diagnostic benefits of blood glucose daily monitoring in carbohydrate metabolism compensation and further adjustments of insulin therapy. Conducted daily monitoring of blood glucose in children and adolescents with type 1 diabetes under subcompensation and compensation and the level of glycated hemoglobin is discussed in the paper. Nocturnal hypoglycemia, hyperglycemia were identified with the CGMS. The procedures allowed adequate correction of insulin doses to achieve target indicators of glycemia and glycosylated hemoglobin.
Key words: сахарный диабет, гликированный гемоглобин, системы суточного мониторирования гликемии, diabetes mellitus, glycated hemoglobin, continuous glucose monitoring system
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STUDY OF ANTI-DIABETIC DRUG MARKET STRUCTURE IN RUSSIA
Kuznetsova N.D., Krikova A.V., Rafalskiy V.V.
UDC: 615.252.349:615.1
Abstract: To investigate anti-diabetic drugs market in Russia and analyze its structure a content analysis of official information sources was used. According to the obtained results the range of anti-diabetic medications used in Russia involves insulins (38.1%) and other hypoglycemic agents (60.3%), which include oral hypoglycemics (58.7%) and drugs for subcutaneous injection (1.6%).
Key words: сахарный диабет, противодиабетические препараты, контент-анализ, diabetes mellitus, anti-diabetic drugs, content analysis
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INTRAPERITONEAL TENSION-FREE PLASTICS IN UMBILICAL HERNIA
Alibegov R.A., Melkonyan S.S.
UDC: 617.55-007.43
Abstract: Results of surgical treatment of 68 umbilical hernia patients are presented in the paper. 32 of the investigated patients were operated with transumbilical access with intraperitoneal implantation Reperen. The control group consisted of 36 patients, operated with conventional methods. The proposed method has a number of advantages. They include low traumatism, cosmetic surgery, and slight postsurgical pain syndrome. Intraperitoneal plastics of the abdominal wall with implants Reperen can be applied in umbilical hernia.
Key words: пупочные грыжи, чреспупочный доступ, интраперитонеальная имплантация, эндопротез Реперен, umbilical hernia, transumbilical access, intraperitoneal plastic, implantation of Reperen
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NEUROOPHTHALMOLOGIC EXAMINATION IN EARLY DIAGNOSTICS OF MULTIPLE SCLEROSIS
Maslova N.N., Andreeva E.A.
UDC: 616.832-004.2:617.7
Abstract: Anatomical, functional and pathogenetic dependence of optical neuritis and multiple sclerosis are discussed in the paper. Diagnostic opportunities of up-to-date visualization and functional research techniques used for early diagnostics of multiple sclerosis in patients with optical neuritis are analyzed in detail. Modern approaches to early diagnostics of multiple sclerosis are considered. Significance of both neurological and ophthalmological inspection of patients for the earliest identification of demyelinating CNS diseases is clearly demonstrated.
Key words: рассеянный склероз, оптический неврит, диагностика, оптическая когерентная томография, зрительные вызванные потенциалы, multiple sclerosis, optical neuritis, diagnostics, optical coherent tomography, the visual caused potentials
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PROPERTIES OF NERVOUS CENTRES. PRINCIPLES OF COORDINATIVE (INTEGRATIVE) ACTIVITY. REFLEX AS AN OPERATIONAL MECHANISM OF THE FUNCTIONAL SYSTEMS (LECTURE FOR STUDENTS)
Pravdivtsev V.A., Evseyev A.V., Bruk T.M.
UDC: 612 (075.8)
Abstract: In the lecture the problems of properties of nerve centers, coordinative (integrative) activity of nerve centers are discussed. It is pointed out that reflex act is an operational mechanism providing adaptive reactions of nerve centers functioning as a part of complete central-peripheral associations, oriented to achieve certain useful results during realization of body natural activity.
Key words: нервный центр, координационная (интегративная) деятельность, рефлекторный акт, функциональная система, nervous centers, coordinative (integrative) activity, reflex act, functional system
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INVENTION: A TECHNIQUE TO REGISTER MECHANICAL ACTIVITY OF AN ISOLATED FROG HEART (PATENT N 2479871)
Sosin D.V., Pravdivtsev V.A., Evseyev A.V.
Abstract: The formulae of invention: a method for registration of a mechanical activity of an isolated frog heart with a record of a curve from a heart placed into Ringer solution for coldblooded animals. The process is monitored with a the reographic computer «Reospectr», with a bipolar technique during the study the first electrode is applied to the investigated area, but the second is puts just into Ringer solution surrounding the heart
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