ACTIVITY OF ENDOGENOUS ALDEHYDES CATABOLISM ENZYMES OF THE BRAIN IN EXPERIMENTAL PUBERTAL AGE RATS UNDER STRESS INFLUENCE
Berezhnaya E. A., Davydov V. V.
UDC: 612.66-015.3616-092.19]:577.15
Abstract: The aim of the study was to estimate peculiarities of activity modulation of endogenic aldehydes redox transformation enzymes in subcellular fraction of the brain in pubertal age rats under prolonged immobilization. Brain cells generated conditions favouring efficient utilization of endogenic aldehydes in redox catabolism pathway under the infl uecenof the stress.
Key words: альдегиддегидрогеназа, альдозоредуктаза, альдегидредуктаза, пубертат, иммоби лизационный стресс, aldehyde dehydrogenase, aldose reductase, aldehyde reductase, puberty, immobilization stress
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SENSITIVITY OF MYOCARDIUM TO ARRYTHMOGENIC FACTORS ACCOMPANIED BY ALCOHOLIC INTOXICATION
Stepanova E. F., Krikova A. V., Novikov V. E., Novikov A. S.
UDC: 615.322:547.814].015:616.12-008.318-092.9
Abstract: Study of sensitivity of the heart in rats followed by repeated introduction of ethanol to action of calcium chloride and strophanthin, the substances realising the effects, accordingly through calcium and natrium channels has been parformed. As the test for definition of sensitivity of heart to action arrithmogenic substances the simple test - time of the beginning of infringements of a warm rhythm and irreversible cardiac arrest has been taken. It has been established that spirit ethyl raises sensitivity of the heart to the action of arrithmogenic factors of calcium of chloride and strophanthin and reduces life expectancy of experimental animals.
Key words: спирт этиловый, аритмия, кальция хлорид, строфантин, spirit ethyl, arrhythmia, calcium chloride, strophanthin
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PHENOMENON OF «PREVENTION PARADOX» IN MALE AND FEMALE DRINKERS
Welcome M. O., Razvodovsky Y. E., Melnichuk V. I., Pereverzeva E. V., Pereverzev V. A.
UDC: 616.89-008.441.13-057.875
Abstract: Data concerning high risk to decrease mental and academic performance of students (involving gender differences), who take alcohol even in small doses confirm the phenomenon of «prevention paradox» in Belarusian population. The study forms the basis to substantiating that the relative safe per session and monthly dose of exogenous ethanol in the form of alcoholic beverages (beer, wine, vodka, and others) for young adults, especially students, practically does not exist.
Key words: алкоголь, студент, успеваемость, вредные последствия, работоспособность, alcohol, student, academic performance, harmful effects, mental performance
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PECULIARITIES OF DIAGNOSTICS OF HEREDITARY MOTOR AND SENSORY CHARCOT-MARIE NEUROPATHY
Pavlov V A., Mayorova N G., Bychkova I. N.
UDC: 616.832-009.55-056.7
Abstract: Case histories of 11 hereditary motor and sensory neuropathy (NMSN) Charcot-Marie patients have neen analysed. The study has highlighted typical and atypical symptoms of the disease and emphasized the role of electroneuromyographic (ENMG) study, the dynamic of clinical observation, DNA diagnostics, and muscle biopsy in the detection of the disease.
Key words: наследственная моторно-сенсорная невропатия Шарко-Мари, типичные и атипич ные симптомы, диагностика, hereditary motor-sensory neuropathy Charcot-Marie, typical and atypical symptoms, diagnostics
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PROS AND CONS OF VIRTUAL COLONOSCOPY
Volkov V. N., Auchynikau V. A.
UDC: 616.345-073.75
Abstract: Virtual colonoscopy is none invasive screening method of colon examination. Beneficial application of virtual colonoscopy has been compared with barium enema and endoscopy in 21 patients with colon pathology. Virtual colonoscopy can be used as an alternative method for the colon study in case of limitations and contraindications for endoscopy and barium enema.
Key words: виртуальная колоноскопия, мультиспиральная компьютерная томография, ирриго скопия, эндоскопия, virtual colonoscopy, multyspiral computed tomography, barium enema, endoscopy
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ARTERIAL HYPERTENSION EPIDEMIOLOGY IN ADULD FEMALE POPULATION OF THE CITY OF SMOLENSK: RESULTS OF MONITORING IN 2007-2010
Agaphonov A. N.
UDC: 616.12-008.331.1-036.22 (470.332)
Abstract: Interest of a modern Cardiology to arterial hypertension in females is due to the high incidence and mortality in females. This increase results from high incidence of risk factors, arterial hypertension being one of the most common (AH). Aim of the study: to study the incidence of (AH) in the females, specific features of AH in females, pharmacoepidemiology, and mortality of the cardio-vascular diseases (CVD). Materials and methods: hypertensive females have been examined. Results: the incidence of AH has increased in women; the knowledge about AH development increased insignificant; the number of women who takes antihypertensive drugs and the number of effiienctly treated patients has increased. The tendency to the decrease of mortality rates due to circulation diseases is clearly seen.
Key words: артериальная гипертония, женщины, распространенность, фармакоэпидемиоло гия, смертность от сердечно-сосудистых заболеваний, arterial high blood pressure, female-patients, incidence, pharmacoepidemiology, mortality due to cardio-vascular diseases
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INCIDENCE OF ARTERIAL HYPERTENTION RISK FACTORS IN YOUNG PATIENTS
Chudayeva O. V.
UDC: 612.143-053.81
Abstract: Arterial hypertension is a multifactoral disease. Development of arterial hypertension in young patients depends on hereditary factors, salt susceptibility and obesity. Keywords: arterial hypertension, risk factors, obesity, heredity, salt susceptibility
Key words: артериальная гипертония, факторы риска, ожирение, наследственность, чувстви тельность к поваренной соли
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COMPREHENSIVE ESTIMATION AND CORRECTION OF METABOLIC DISORDERS IN CHILDREN WITH CONGENITAL HYPOTHYROIDISM
Alimova I. L., Romankova T. M., Suchorukov B. S.
UDC: 616.441-008.64-053.37:612.015.39
Abstract: Comprehensive investigation of lipid and cellular power metabolism in 48 children with congenital hypothyroidism has been performed. Participants of the investigation, being at different stages of disease indemnification, had replacement therapy with thyroxin. The most severe metabolic disorders (dislipidemia and disturbances in aerobic and anaerobic processes of a cellular power metabolism) were revealed in a subindemnification stage of hypothyroidism. However in an indemnifi cation stage hypertriglyceridemia together with the strain of aerobic processes in cellular power metabolism were detected. It has been demonstrated that in case of a stable thyroid function indemnification administation of L-carnitine facilitates improvement of lipid and cellular power metabolism in children with congenital hypothyroidism.
Key words: врожденный гипотиреоз, дети, липидный обмен, цитохимические ферменты, L-карнитин, congenital hypothyroidism, children, lipid metabolism, cytochemical enzymes, L-carnitine
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GENERAL PRACTITIONER’S ASSESSMENT OF COMPLIANCE AND MENTAL STATUS IN EROSIVE GASTRITIS PATIENTS
Afanasenkova T. E.
UDC: 616.33-002.2
Abstract: Correlation of chronic erosion patients’compliance and their psychological features has benn studied. It has been established, that more than half of surveyed patients have clinically confirmed neurotic semiology and they differ from other patients according to low index of complience. The features of the gastritis patients should be taken into consideration when medical and rehabilitation activities are developed.
Key words: гастрит, комплаенс, психологический статус, chronic erosions gastritis, complaensa, psychological features
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ANTIOXIDANTS AND ANTIHYPOXANTS IN THE PHARMACEUTICAL MARKET: DATA OF PHARMACEUTICAL WORKERS SURVEY
Krikova A. V., Rafalsky V. V.
UDC: 615.1+614.27
Abstract: In order to obtain valid information concerning demand for antioxidants and antihypoxants in the pharmaceutical market of Smolensk Region a survey of pharmaceutical workers has been carried out. In the Smolensk regional pharmaceutical market such antioxidants and antihypoxants as mildronat and actovegin are of great demand. Vitamin E and mexidol take the second rank. The major factor generating antioxidants and antihypoxants customer’s demand is a physician’s prescription. Other methods of customers’ demand organization such as merchandizing and packing have been shown to be less effi cient.
Key words: антиоксиданты, антигипоксанты, анкетирование, фармацевтические работники, аптечные учреждения, antioxidants, antihypoxants, survey, pharmaceutical workers, pharmaceutical market
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STUDY OF ENUCLEATION STRUCTURES AND PATHOMORFOLOGICAL FEATURE OF THE EYES AFTER THE TERMINAL GLAUCOMA DEVELOPMENT
Malachova A.I.
UDC: 617.7-007.681:617.7-089.87
Abstract: The purpose of the study was to perform structural analysis of enucleation eyes and the pathomorphology analysis of eyes, enucleation concerning a terminal stage of glaucoma (2003-2009). Staining of the samples was performed with a few techniques. The glaucoma still remains the leader of enucleation (63%). Morphological changes are found out in all coats of eyes. The greatest changes in glaucoma develop in fibrous coat of eyes and inferior segment of the vascular coat that, most likely, is primary in pathogenesis of open angle glaucoma. Changes in the posterior vascular coat and retina are secondary ones.
Key words: глаз, энуклеация, глаукома, eye, enucleation, glaucoma
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CLINICAL AND BIOCHEMICAL COMPARISONS OF PATIENTS WITH ALCOHOLIC LIVER CIRRHOSIS COMPLICATED BY HEPATIC ENCEPHALOPATHY
Smolina S. P., Petrova M. M., Sharobaro V. I., Fedorov G. N.
UDC: 616.36-004+615.242.3
Abstract: Studied laboratory records in alcoholic liver cirrhosis patients with hepatic encephalopathy. The degree of hepatic encephalopathy was assessed by clinical and psychometric testing method. Identifi ed the relationship between biochemical indices of blood plasma and the degree of hepatic encephalopathy in patients with alcoholic liver cirrhosis.
Key words: алкогольный цирроз печени, печеночная энцефалопатия, биохимические показатели, alcoholic liver cirrhosis, hepatic encephalopathy, biochemical indices of blood plasma
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ANALYSIS THE MANAGEMENT STRATEGY OF PATIENTS WITH CORONARY SYNDROMES WITHOUT ELEVATION ST SEGMENT WITH HIGH RISK OF AN UNFAVORABLE OUTCOME
Khokhlova Y. A., Kozyrev O. A.
UDC: 616.12-005.4-08:616.127-005.8:616.127-005.8
Key words: острый коронарный синдром без подъема сегмента ST, тактика ведения, риск не благоприятных исходов, acute coronary syndromes without ST segment elevation, management strategies, risk of an unfavorable outcome
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FREE-RADICAL OXIDATION OF LIPIDS AND CYTOLYTIC SYNDROME IN CHRONIC HEPATITIS PATIENTS WITH VARIOUS ETIOLOGICAL FACTORS
Yankovaya T. N., Nikitin G. A.
UDC: 616.36-002.2-02
Abstract: In the study rates of free-radical oxidation of lipids and cytolytic syndrome in blood serum in chronic hepatitis patients with various etiological factors have been estimated. Considerable decrease of total antioxidizing activity has been demonstrated in combination of two etiological factors: a virus infection and alcoholic intoxication.
Key words: свободнорадикальное окисление, цитолитический синдром, хронический гепатит, free-radical oxidation, a cytolytic syndrome, chronic hepatitis
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COMPLIANCE OR PATIENTS’ LOYALTY TO THERAPY: CURRENT SITUATION AND FEATURE IN BRONCHIAL ASTHMA
Molotkov A. O., Punin A. A., Molotkova S. A., Evseeva I. P.
UDC: 616.248-08
Abstract: Comprehensive analysis of current situation concerning сompliance or patients’ loyalty to therapy in therapeutical patients has been carried out. Particular attention has been paid to bronchial asthma patients. Certain recommendations to improve the situation have been developed.
Key words: комплаенс, приверженность лечению, бронхиальная астма, сompliance, patients’ loyalty to therapy, bronchial asthma
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COMPLIANCE OF ARTERIAL HYPERTENSION PATIENTS AND THE WAYS OF ITS IMPROVEMENT
Filippova Yu. M.
UDC: 616.12-008.331.1-084
Abstract: Despite a wide range of antihypertensive drugs and up-to-date methods of treatment the results of therapy in patients with arterial hypertension are still poor. One of the reasons is a low compliance to treatment. The formation of this compliance is a process which depends on various factors. The improvement of the process of treatment and psychotherapeutic infl uence on patients are the main factors in this progress.
Key words: артериальная гипертензия, приверженность к лечению, arterial hypertension, compliance
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PROBLEM OF PROVISION OF MEDICAL CARE AGAINST A PATIENT’S WILL
Barinov S. A.
UDC: 615.27
Abstract: In this article the problem of forced rendering medical aid to a patient without his will with the permission of the court. The author gives concrete proposals on this issue. Keywords: medical activities, the rights of the patient, the patient’s will to a medical intervention, enforcement of medical intervention
Key words: медицинская деятельность, права пациента, воля пациента на медицинское вмеша тельство, принудительное осуществление медицинского вмешательства
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APPLICATION OF COMBINED ANTIBACTERIALS IN OPHTHALMOLOGY
Deev L. A., Belkova A. G., Malahova A. I., Voitova S. P.
UDC: 617.7+615.281
Abstract: Inflammatory eay diseases account for more than 40% of outpatient reception hours of an eye doctor, as well as about 80% of cases of disability. Inflammatory eye diseases can be caused by varoius infection agents. In the treatment of these diseases different combined antibacterials can be benefially used. Efficient treatment of inflammatory eye diseases with wide-spectrum antibiotics with low resistance to microorganisms causing the disease and low risk of side effects has been proved.
Key words: воспаление, глаз, антибактериальный, an infl ammation, an eye, antibacterial
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EARLY DIAGNOSTICS AND PREVENTION OF ARTERIAL HYPERTENSION IN POPULATION OF TECHNOLOGICALLY-POLLUTED AREAS
Panova Yu.G.
UDC: 616-005.2
Abstract: The analysis of the tactics of treatment of patients with essential hypertension living in ecologically ifferent areas of the Bryansk region has been made. The methodological approaches to the treatment of patients out of 10 districts, ranked by 6 ecological groups according to the degree of radioactive, chemical, and combined radiation-chemical pollution of the environment have been analysed. A comprehensive clinical and diagnostic study included working middle-aged patients (237 men) from different ecological regions, both genders and the same age range (35-45 years). The impact of character and level of technogenic pollution on the severity and degree of arterial hypertension, presence of concomitant cardiovascular disease and, accordingly, the tactics of their treatment have been studied. High level of technogenic, radioactive and pesticidal pollution increases quantity of components of treatment, complicates the control of arterial pressure.
Key words: артериальная гипертензия, комбинированная терапия, радиоактивное загрязнение, химическое загрязнение окружающей среды, arterial hypertension, combined therapy, radioactive pollution, chemical environmental contamination
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PHENOMENON OF LONELINESS IN CONTEXT OF PHYSICAL AND SPIRITUAL HEALTH OF AN INDIVIDUALITY
Sinitsyn S. N.
UDC: 1:301.085:15
Abstract: In this article we discover questions, connected with the problem of «the solitude». We pay special attention on the definition of the so called «periods» or emotional levels of the solitude and describe different forms of overcoming of lonliness and different opportunities to care in the situation. Particular attention is paid to non-formal social relations and groups of interests.
Key words: одиночество, изоляция, потребность общения социальное несовершенство, деви антное поведение, неформальные социальные связи, solitude, isolation, necessity of communication, social imperfection, deviation behavior, non-formal social relations
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