MIOCARDIAL CHANGES IN RADIOTHERAPY
Volkov V. N., Auchynikau V. A.
UDC: 616.24-006.6:615.849.114):616.12-085
Abstract: Morphological and functional conditions of the myocardium have been estimated during the course of radiation therapy in lung cancer patients. Sinus tachycardia, increase of left ventricular contractile function and atrial ectopic activity caused by the autonomic nervous system imbalance due to significant reduction in vagal component and the relative dominance of sympathic have been revealed. Correlation analysis has demonstrated that these changes have a significantly increasing character as a delayed manifestation after completion of radiotherapy.
Key words: миокард, лучевая реакция, автономная нервная система, myocardium, radiation injury, autonomic nervous system
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FEATURES OF TEMPORAL ENDOCARDIAL ARTIFICIAL PACING IN PATIENTS WITH RECURRENT MYOCARDIAL INFARCTION
Osmolovsky A. N., Babyenkova L. V.
UDC: 616.127-005.0-08
Abstract: Objective of the study: to confirm the necessity of substantiation and the elaboration of the endocardiac electrode reposition method in the right ventricle cavity in spontaneous discontinuation of temporary electrocardiostimulation in patients with recurring myocardial infarction. The efficient and secure method of endocardiac electrode reposition providing electrode back passing from the venous bed into the right ventricle cavity, cardiostimulation with electric impulses and the creation of new contacts of electrode with right ventricle endocardium with the presence or absence of cardiac conduction and excitability functions was worked out and introduced into clinical practice. The endocardiac electrode reposition method excludes electrode dislocation from the right ventricle cavity, allows electrode and endocardium fixation and provides the heart with stable artificial rhythm in a minimum time period. The described endocardiac electrode reposition method was used on 23 patients with acute bradyarrhythmia of infarct genesis and allowed to restore efficient artifitial rhythm at the spontaneous discontinuation of electrocardiostimulation.
Key words: инфаркт миокарда, брадиаритмии, временная электрокардиостимуляция, myocardial infarction, bradyarrhythmia, temporary electrocardiostimulation
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LEVEL OF ANXIETY IN PREGNANT WOMAN, MEDICAL AND SOCIAL FACTORS INFLUENCING IT
Sumrach M. U., Bogdan O. G., Sinitskaya A. V.
UDC: [616.891.6:618.2]:303.62
Abstract: The level of anxiety in pregnant women is characterised according to the analysis of questionnaire data, the factors influencing it are revealed. The interrelation with situational and personal uneasiness of such factors as age, residing, education, social and marital status, self-estimation of state of health, of pregnancy, mutual relations with the partner, and violence in family have been investigated. Influence of pregnancy and medical supervision on the level of situational uneasiness of women has been studied. The original sociological toolkit with inclusion in it scales of self-estimation of level of uneasiness (Ch. D. Spilberger, Ju. L. Hanin) has been used.
Key words: ситуативная тревожность, личностная тревожность, беременность, самооценка состояния здоровья, социальные факторы риска, situational uneasiness, personal uneasiness, pregnancy, self-estimation of state of health, social risk factors
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ANTIHYPOXIC ACTION OF SELENIUM CONTAINING METAL COMPLEX SUBSTANCES IN VARIOUS MODES OF ADMINISTRATION
Sosin D. V., Yevseyev A. V., Parfenov E. A., Pravdivtsev V. A., Yevseyeva M. A.
UDC: 616-001.8:615.355
Abstract: In experiments on mice undergone to an acute hypercapnic hypoxia and an acute hypobaric hypoxia a screening of antihypoxants among new selenium containing metal complex substances was performed after their intra-abdominal and oral introductions. It was found that substances πQ1983 and πQ2170 on both models of hypoxia make the defensive effects surpassing actions well-known antihypoxants such as amthizole and bemythil. It was established that antihypoxiс affects of studied substances depend on their caused hypothermia. For the first time the protective action of selenium containing metal complex compounds was demonstrated after their introduction per os.
Key words: мыши, острая гипоксия, антигипоксанты, способы введения, mice, acute hypoxia, antihypoxants, mode of administration
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EFFICIENCY OF BEMYTHYL AND DIOSMIN IN STRESS IN EXPERIMENTAL ANIMALS
Krjukova N. O., Novikov V. E.
UDC: 615.27
Abstract: In article results of experimental researches on influence diosmin and mexidol on stress are presented. Estimate «triad» stress damage and intensity of lipid peroxidation in blood serum and stomach homogenate of experimental animals. Thus, diosmin and mexidol protect stomach mucous membrane from stress damages, reduce weight of the adrenal glands and increase thymus weight, i. e. diosmin and mexidol possess stress-protective activity. Diosmin and mexidol reduces lipid peroxidation in whey of blood and stomach homogenate of animals. On the basis of the received results we draw a conclusion that diosmin and mexidol possess stress protective properties.
Key words: стресс, перекисное окисление липидов, диосмин, мексидол, stress, lipid peroxidation, diosmin, mexidol
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DIAGNOSIS OF LUNG CANCER WITH ATELECTASIS
Auchynikau V. A., Volkov V. N.
UDC: 616.24.006.6-073.756.8
Abstract: Comparison of CT and MRI methods has proved that MRI is a highly informative method in the d iagnosis of central lung cancer with atelectasis and allows identifying the gross volume tumor with atelectasis in 95,8% cases due to marked differences in signal intensity. CT does not give a detailed characterization of the tumor in the same situation in a half of the cases. In order to improve post-processing CT images was suggested the window, which improves the visualization of the tumor contours from 16, 7 to 20,8%.
Key words: центральный рак легкого, ателектаз, мультиспиральная компьютерная томогра фия, магнитно-резонансная томография, central lung cancer, atelectasis, multispiral computed tomography, magnetic resonance imaging
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PROBLEM OF IODINE DEFICIENCY IN SMOLENSK REGION: THE PAST AND THE PRESENT
Alimova I. L., Romankova T. M., Pashinskaya N. B., Nesterov E. G.
UDC: 612.392.64-053.2 (470.332)
Abstract: The results of epidemiological studies, which were carried out in 1998-1999 according to WHO-criteria (1991), demonstrated the presence of mild-moderate iodine deficiency in the Smolensk region. Iterated studies, which were carried out in 2009 by members of FSI “Endocrinological scientific center” in collaboration with local health authorities, have confirmed the persisting unfavourable situation in iodine prevention among the population of Smolensk region. The final results of the study emphasize the necessity of strengthened informational activity among the population, devoted to the popularization of knowledge regarding the problem of iodine defi ciency, as well as the purposes and value of iodine prevention.
Key words: йодный дефицит, дети, гипотиреоз, неонатальный скрининг, профилактика, iodine defi ciency, children, hypothyroidism, newborn screening, prevention
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AEROPALYNOLOGICAL CONTROL OF THE ENVIRONMENT AND RESULTS OF POLLEN MONITORING IN SMOLENSK IN 2009-2010
Slabkaya E. V., Meshkova R. Y., Aksyonova S. A.
UDC: 616.211-002. 193-056.3 (470.332)
Abstract: The article provides description of up-to-date methods to detect concentration of pollen the atmosphere and principles to create a calendar of pollination in accordance with international standards. The article also provides the most allergic taxons for the studied area. The experimental part includes results of a comparative analysis of pollen monitoring for 2 years, correlation between the level of pollination and weather and climate conditions and the infl uence of pollination level on incidence and course of seasonal allergies.
Key words: пыльцевой мониторинг, пыльца, поллиноз, pollen monitoring, pollen, polinosis
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ESTIMATION OF EFFICIENCY OF METFORMIN CONCERNING INDICATORS OF THE LIPID SPECTRUM OF BLOOD, LEVELS OF GLICEMIA AND URICEMIA IN PATIENTS WITH METABOLIC SYNDROME
Vasilyva L. V., Lakhin D. I.
UDC: 615.036.8
Abstract: The article is devoted to the problem of increase efficiency treatment in patients with metabolic syndrome (МS). The study involved 65 patients with diagnosed МS. Patients of the basic group received siofor in a dosage of 500 mg 2 times a day for 12 months. As a result of administration siofor it has been noted that it is possible to reach significant decrease in the level of glucose and uric acid, as well as positive infl uence of the medicine on all basic components of the lipid spectrum of blood.
Key words: метаболический синдром, сиофор, метформин, липидный спектр крови, гликемия, урикемия, a metabolic syndrome, siofor, metformin, a lipid spectrum of blood, glicemia, uricemia
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SPONTANEOUS ESOPHAGEAL RUPTURE
Zabrosaev V. S., Sokolov V. N., Minchenkov V. L., Pisanka V. V.
UDC: 616.329-072.1-089
Abstract: Spontaneous esophageal rupture (SER) is a disorder complicated for diagnosis and dangerous for patience’s life. Lack of a considerable experience leads to diagnostic pitfalls and delayed surgical intervebtion. Mortality rate in patients comes up to 85%. In this study a retrospective analysis of six cases of SER in patients undergone a course of medical treatment in the Department of Thoracic Surgery of Smolensk Regional Clinical Hospital (SRCH) in the period of 1999-2009 has been presented.
Key words: пищевод, спонтанный разрыв, диагностика, лечение, esophagus, spontaneous rupture, diagnostics, treatment
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DENTAL STATUS IN STUDENTS OF SMOLENSK HIGHER AND SECONDARY SCHOOLS
Antsupova O. A., Goncharova I. S., Goncharova E. M., Rusakova P. U., Snegireva L. V., Goleva N. A., Scherbakova T. E.
UDC: 616.314-002.4-039.71
Abstract: Epidemiological researches are the basis for evaluation of dental status of the population and determination of its needs for the preventive and medical care. The aim of research was to evaluate the prevalence of major dental diseases and their intensity in the Smolensk students.
Key words: распространенность и интенсивность стоматологических заболеваний, студенты, prevalence, intensity, dental diseases, students
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SELF-ASSESSMENT OF FACTORS INFLUENCING ON THE THERAPEUTIC DENTISTS WORKING CAPACITY AND WORKLOAD (IN THE OUT-PATIENTS’ CLINIC OPERATING IN THE SYSTEM OF COMPULSORY HEALTH INSURANCE)
Tsepov L. M., Shcherbakova T. E., Nikolaev A. I.
UDC: 616.31:614.255.5
Abstract: Self-assessment of factors influencing on the therapeutic dentists working capacity and workload has been studied in the city out-patient clinics. A sociological method with specially developed questionnaire has been used. The results of survey have been analyzed. Dental care quality has been evaluated. Dentists’ attitude toward the work has been studied. Their opinion on professional and personal abilities of the staff has been assessed as well as moral and psychological climate in the group.
Key words: самооценка, уровень квалификации, стоматологическая помощь, обязательное ме дицинское страхование, self-assessment, qualifi cation level, dental health care, compulsory health insurance
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PARAMETERS ANTIOXIDATIVE PROTECTION IN PATIENTS WITH CHRONIC HEPATITES AND LIVER CIRRHOSIS TREATED IN OUT-PATIENT DEPARTMENTS
Yankovaya T. N.
UDC: 616.36-002.2:616.36-004+577.153
Abstract: Terms of antioxidative protection in blood serum in patients with chronic hepatites and liver cirrhosis have been studied. Decrease in total antioxidizing activity and antioxidative systems сeruloplasming-transferring in blood serum has been particularly marked in patients with liver cirrhosis.
Key words: антиоксидантная система, церулоплазмин, трансферрин, хронический гепатит, цирроз печени, antioxidative system, сeruloplasming, transferring, chronic hepatites, cirrhosis of a liver
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CAUSES OF ERADICATIVE THERAPY FAILURE IN GASTRODUODENAL ULCER PATIENTS
Abramova E. S., Nikitin G. A., Fedorov G. N.
UDC: 616.33-002.44+615.015
Abstract: Principal scientific directions to study eradicative therapy failure in gastroduodenal ulcer disease have been reviewed. 5 principal causes have been considered: Helicobacter pylori resistance to antibiotics, persistence Helicobacter pylori in the oral cavity, features of reactivity chage of a macroorganism, transition in coccal form, presence of concomitant virus, bacterial and fungous fl ora in the mucous membrane of the stomach.
Key words: язвенная болезнь, Heliсobacter pylori, сопутствующая микрофлора, резистентность, gastroduodenal ulcer disease, Helicobacter pylori, concomitant microfl ora, resistance
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MODERN ANTISPASMODICS IN PRACTICE OF GASTROENTEROLOGIST
Dekhnich N. N.
UDC: 616.3:615.784
Abstract: Spasm of smooth muscle cells of internal organs underlies both chronic and acute pain during the course of different gastrointestinal diseases and hence the frequent use of antispasmodic drugs. This article reviews available in the literature data on clinical aspects of currently used antispasmodics.
Key words: спазмолитики, эффективность, нежелательные лекарственные реакции, antispasmodic drugs, effi ciency, adverse drug reactions
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METODS OF ACTIVE DETOXICATION IN COMBINATED INTENSIVE CARE IN ALCOHOLIC CIRRHOSIS
Yakubov D. A., Petrova M. M., Petrov V. S., Minchenkova V. N., Nikolaev S. V.
UDC: 616.36-004-08:616.89-008.441.13
Abstract: Characteristics of methods of active detoxication with to manage alcoholic cirrhosis have been discussed in the article. Special attention is paid to decompensation mechanisms.
Key words: активная детоксикация, алкогольный цирроз, active detoxication, alcoholic cirrhosis
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ETHIOLOGY AND TERMS OF DEVELOPMENT OF GASTROESOPHAGEAL REFLUX DISEASE
Podcheko P. I.
UDC: 616.329-002-02
Abstract: According to the literature data gastroesophageal reflux disease is considered to be polyethiological conditions that may be caused by dysfunction of low oesophageal sphincter, diaphragmal hernia, peptic ulcer disease, conditions associated with increased intra-abdominal pressure such as pregnancy, ascites, abdominal fl atulence, obesity, intake of some medicines, oesophageal dismotility, etc. But it is a mistake. The real causative agents of gastroesophageal reflux disease are hydrochloric acid and pepsin of gastric juice and/or bile acids, lysolecithin of duodenal content. These substances may have prolonged contact with oesophageal mucosa due to pathological gastroesophageal refl ux and their slowed-down clearance.
Key words: гастроэзофагеальная рефлюксная болезнь, соляная кислота, желчные кислоты, па тологические гастроэзофагеальные рефлюксы, gastroesophageal reflux disease, hydrochloric acid, bile acids, pathologic gastroesophageal reflux
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MODERN CONCEPTION OF INTERFERON SYSTEM
Vavilenkova J. A.
UDC: 616-018.1
Abstract: It has been described the main sentences according to the interferon system, development, molecular structure, classification of different interferon types. Mechanisms of IFN-system activation, IFN-status in healthy persons, in different pathologic processes and in allergic diseases were described in this article.
Key words: система интерферона, α-интерферон, γ-интерферон, иммунитет, аллергические заболевания, the interferon system, α-interferon, γ-interferon, immunity, allergic diseases
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METABOLIC PROTECTION IN ARTHRITIS
Новиков В. Е.
UDC: 615.276.4
Abstract: The review considers pharmacodynamics and clinical applications of drugs with metabolic type of action which stimulate regeneration and provide protective action on articular cartilage in osteoarthritis. The review analyses the data of the experimental and clinical trials of the most common chondroprotective agents
Key words: остеоартроз, метаболическая протекция, хондропротекторы, хондроитин сульфат, osteoarthritis, metabolic protection, chondroprotective agents, chondroitin sulphate
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ARTERIAL HYPERTENSION «WHITE COAT» IN CHILDREN AND ADULTS, ITS INCIDENCE AND CLINICAL PROGNOSTIC VALUE
Faqih Ibrahim Mounir, Bekezin V. V.
UDC: 616.12-008.331.1
Abstract: This article provides an overview of the literature devoted to the study of aspects of the prevalence and clinical and prognostic signifi cance of «white coat» hypertension in adults and children. Most studies have shown a high cardiovascular risk (left ventricular hypertrophy, myocardial infarction, stroke and others) in children and adults with «white coat» hypertension, which requires further study of this problem.
Key words: артериальная гипертензия «белого халата», дети, взрослые, «white coat» hypertension, children, adults
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